Friday, September 21, 2012
Evolving genomic transcriptional networks
"Combining transcriptomic and signaling data, we develop an evolutionary computational procedure that allows obtaining alternative genomic transcriptional regulatory network (GTRN) that still maintains its adaptability to dynamic environments. We apply our methodology to an E. coli GTRN and show that it could be rewired to simpler transcriptional regulatory structures." Full paper @
PNAA
PNAA
Labels: evolutionary algorithms, gene regulation, synthetic biology, systems biology