Wednesday, May 08, 2024

 

How DNA encodes the start of transcription

Very cool use of machine learning to infer more precise rules of RNA transcription from DNA, including, strength, local and long-rage instructions: "The rules rely on three types of sequence patterns: motifs, initiators, and trinucleotides. The nine motifs are the main drivers of transcription initiation signals and can have short- or long-distance effects. The 11 initiators fine-tune transcription initiation signals but only have local effects. The 32 trinucleotides (representing all three-nucleotide combinations of A, C, G, and T) account for the remaining sequence dependencies not captured by motifs and initiators and have mostly local effects." Full news article and the original paper @ Science.

Labels: , , ,


This page is powered by Blogger. Isn't yours?