Tuesday, April 07, 2009


Gene Expression--Where to Start?

"To convert the encoded genetic information from eukaryotic DNA into proteins, base sequences of genes are first transcribed into RNA by RNA polymerase II. To produce functional RNA molecules, dozens of accessory factors are needed to define the proper locations for RNA polymerase II to begin and end transcription. Although we have some basic knowledge about how these factors work, it is still not possible to take a eukaryotic genome sequence and accurately predict what RNA species it will produce. Recent efforts to map and sequence "transcriptomes" have only increased the challenge by revealing a much more complex set of RNAs than expected, including many that do not produce proteins". Full article @ Science

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