Sunday, September 10, 2023

 

Genomic Complexity or Variation in Drastic Fitness Changes

I am fascinated by the recent evidence showing that Polyploidy may grant evolutionary advantages in the presence of drastic fitness changes (e.g. cataclysms). One option is that extra chromosomes may increase connectivity of gene regulatory networks--- fascinating work from van de Peer on that note.


 The results remind me of computational experiments we did a long time ago with RNA Editing, where we experimented with drastic fitness changes (simulated cataclysms) and emergence of memory. RNA Editing, we started arguing long ago, also adds additional regulatory variety and proves advantageous in drastic fitness changes---though RNA editing works by adding more variants, not greater number of regulatory possibilities (network connectivity) as it is hypothesized for polyploidy. Maybe this explains why the latter is maladaptive in stable fitness landscapes, whereas RNA Editing often isn't? 





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