Friday, November 08, 2013


Genetics Driving Epigenetics

"Humans vary according to a plethora of traits, such as height, hair color, behavior, and susceptibility to disease. Both genetics (nature) and environment (nurture) contribute to this variation. Recent large-scale genetic studies have identified thousands of specific DNA variations in the human population that are associated with different traits. However, these studies do not answer a key question: By what means do most DNA variants alter cellular behavior and contribute to differences in specific traits, such as height? A trio of papers [...] find that DNA variants influence a layer of gene regulation called epigenetics through the sequence-specific activity of transcription factors." Perspective @ Science

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