Friday, March 08, 2013


The Other Revolution in the Life Sciences

'I first read the paper by Fritz Lipmann titled "Metabolic generation and utilization of phosphate bond energy" (4). This historic paper introduced the notion of the "high-energy phosphate bond," symbolized by Lipmann's famous "squiggle," together with the accompanying key concepts of group potential and group transfer. This paper, even though published 3 years before Schrödinger's celebrated book, was most probably unknown to him. It clarified for the first time the second property singled out by Schrödinger in his definition of life: its ability to extract "negative entropy," better known to chemists as "free energy," from the environment and convert it into chemical and other forms of work.' Full letter @ Science


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