Tuesday, May 15, 2012

 

Rewiring the Networks for Cancer Treatment

Systems biology (from a complex system viepoint) starts producing important and practical results. "A systems-level analysis shows that, after their oncogenic signaling pathways are perturbed, tumor cells become more sensitive to DNA-damaging chemotherapy." Rewiring the Networks -- Foley 5 (224): ec135 -- Science Signaling. See also:

M. J. Lee, A. S. Ye, A. K. Gardino, A. M. Heijink, P. K. Sorger, G. MacBeath, M. B. Yaffe. [2012] Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell 149, 780–794.


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